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BackgroundPatients with immune-mediated rheumatic diseases (IMRDs) have been prioritized for COVID-19 vaccination to mitigate the infection severity risks. Patients with rheumatoid arthritis (RA) are at a high risk of severe COVID-19 outcomes, especially those under immunosuppression or with comorbidities associated. However, few studies in the literature assessed the safety and immunogenicity of the COVID-19 heterologous vaccine schedules in patients with RA.ObjectivesEvaluate the safety and immunogenicity of two heterologous vaccine schedules against SARS-CoV-2 in patients with RA.MethodsThese data are from the study "SAFER - Safety and Efficacy on COVID-19 Vaccine in Rheumatic Diseases,” a Brazilian multicentric prospective phase IV study to evaluate COVID-19 vaccine in IMRDs in Brazil. Immunogenicity and adverse events (AEs) in patients with RA of all centers were assessed after two doses of ChAdOx1 plus additional dose of BNT162b2 or after two doses of inactivated SARS-CoV-2 vaccine CoronaVac plus additional dose of BNT162b2. The titers of neutralizing antibodies against the receptor-biding domain of protein spike (S) of SARS-CoV-2 (anti-RBD) were measured by chemiluminescence test after each dose of immunizers. Proportions between groups were compared using the chi-square and Fisher's exact tests for categorical variables. Clinical Disease Activity Index (CDAI) before and after vaccination was assessed using the McNemar test.ResultsA total of 107 patients with RA were include in the study, most of them female, with a mean age of 46 years. Biological disease modifying anti-rheumatic drugs (DMARDs) were used by 50 % of the patients and conventional synthetics DMARDs in 48 %. Two doses of CoronaVac plus additional dose of BNT162b2 was used in 66 patients and two doses of ChAdOx1 plus additional dose of BNT162b2 in 41. Only mild AEs were observed, mainly after the first dose. The most common AEs after all doses, regardless of the immunizer type, were pain at the injection, headache, arthralgia and myalgia. ChAdOx1 had a higher frequency of pain at the injection (66% vs 32 %, p < 0,001) and arthralgia (68% vs 15%, p < 0,001) compared to CoronaVac. No patients had flare after the vaccination. The titers of anti-RBD after two doses of ChAdOx1 were higher compared to two doses of CoronaVac (6,03 BAU/mL vs 4,67 BAU/mL, p < 0,001). However, after the additional dose of BNT162b2, the anti-RBD titers were similar in both groups (7.28 BAU/mL vs 7.06 BAU/mL, p = 0.56). Only two cases of COVID 19, with mild symptoms, were reported, one in each group.Figure 1.ConclusionChAdOx1, CoronaVac, and BNT162b2 vaccines are safe in RA patients. The frequency of local adverse effects, particularly pain at the injection site, is high. AEs are more frequent with ChAdOx1, especially after the first dose. The use of the immunizers does not change the degree of inflammatory activity of the disease. The immunogenicity of the two heterologous regimens analyzed was similar.References[1]Marques C, Kakehasi AM, Gomides APM, Paiva EDS, Dos Reis Neto ET, Pileggi GCS, et al. A Brazilian Cohort of Patients With Immuno-Mediated Chronic Inflammatory Diseases Infected by SARS-CoV-2 (ReumaCoV-Brasil Registry): Protocol for a Prospective, Observational Study. JMIR Res Protoc.[2]Medeiros-Ribeiro AC, Aikawa NE, Saad CGS, Yuki EFN, Pedrosa T, Fusco SRG, et al. Immunogenicity and safety of the CoronaVac inactivated vaccine in patients with autoimmune rheumatic diseases: a phase 4 trial. Nat Med. 2021;27(10):1744-1751.[3]Machado PM, Lawson-Tovey S, Strangfeld A, Mateus EF, Hyrich KL, Gossec L, et al. Safety of vaccination against SARS-CoV-2 in people with rheumatic and musculoskeletal diseases: results from the EULAR Coronavirus Vaccine (COVAX) physician-reported registry. Ann Rheum Dis. 2022;81(5):695-709.[4]Tavares ACFMG, Melo AKG, Cruz VA, Souza VA, Carvalho JS, Machado KLLL, et al. Guidelines on COVID-19 vaccination in patients with immunemediated rheumatic diseases: a Brazilian Society of Rheumatology task force. Adv Rheumatol. 2022;62:3.Acknowledg ments:NIL.Disclosure of InterestsNone Declared.
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SARS-CoV-2 rapid spread required urgent, accurate, and prompt diagnosis to control the virus dissemination and pandemic management. Several sensors were developed using different biorecognition elements to obtain high specificity and sensitivity. However, the task to achieve these parameters in combination with fast detection, simplicity, and portability to identify the biorecognition element even in low concentration remains a challenge. Therefore, we developed an electrochemical biosensor based on polypyrrole nanotubes coupled via Ni(OH)2 ligation to an engineered antigen-binding fragment of heavy chain-only antibodies (VHH) termed Sb#15. Herein we report Sb#15-His6 expression, purification, and characterization of its interaction with the receptor-binding domain (RBD) of SARS-CoV-2 in addition to the construction and validation of a biosensor. The recombinant Sb#15 is correctly folded and interacts with the RBD with a dissociation constant (KD) of 27.1 ± 6.4 nmol/L. The biosensing platform was developed using polypyrrole nanotubes and Ni(OH)2, which can properly orientate the immobilization of Sb#15-His6 at the electrode surface through His-tag interaction for the sensitive SARS-CoV-2 antigen detection. The quantification limit was determined as 0.01 pg/mL using recombinant RBD, which was expressively lower than commercial monoclonal antibodies. In pre-characterized saliva, both Omicron and Delta SARS-CoV-2 were accurately detected only in positive samples, meeting all the requirements recommended by the World Health Organization for in vitro diagnostics. A low sample volume of saliva is needed to perform the detection, providing results within 15 min without further sample preparations. In summary, a new perspective allying recombinant VHHs with biosensor development and real sample detection was explored, addressing the need for accurate, rapid, and sensitive biosensors.
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Objectives: To evaluate the safety and immunogenicity of CoronaVac and ChAdOx1 vaccines against SARS-CoV-2 in patients with Rheumatoid Arthritis (RA). Method(s): These data are from the 'SAFER (Safety and Efficacy on COVID-19 Vaccine in Rheumatic Diseases)' study, a Brazilian multicentric longitudinal phase IV study to evaluate COVID-19 vaccine in immunomediated rheumatic diseases (IMRDs). Adverse events (AEs) in patients with RA were assessed after two doses of ChAdOx1 or CoronaVac. Stratification of postvaccination AEs was performed using a diary, filled out daily. The titers of neutralizing antibodies against the receptor-biding domain of SARS-CoV-2 (anti-RBD) were measured by chemilumine scence test after each dose of immunizers. Proportions between groups were compared using the Chi-square and Fisher's exact tests for categorical variables. Clinical Disease Activity Index (CDAI) before and after vaccination was assessed using the McNemar test. Result(s): A total of 188 patients with RA were included in the study, most of them were female. CoronaVac was used in 109 patients and ChAdOx1 in 79. Only mild AEs were observed. The more common AEs after the first dose were pain at injection site (46,7%), headache (39,4%), arthralgia (39,4%) and myalgia (30,5%), and ChAdOx1 had a higher frequency of pain at the injection site (66% vs 32 %, p alpha 0.001) arthralgia (62% vs 22%, p alpha 0.001) and myalgia (45% vs 20%, p alpha 0.001) compared to CoronaVac. The more common AEs after the second dose were pain at the injection site (37%), arthralgia (31%), myalgia (23%) and headache (21%). Arthralgia (41,42 % vs 25 %, p = 0.02) and pain at injection site (51,43% vs 27%, p = 0.001) were more common with ChAdOx1. No patients had a flare after vaccination. The titers of anti-RBDafter two doses of ChAdOx1 were higher compared to two doses of CoronaVac (6,03 BAU/mL vs 4,67 BAU/mL, p alpha 0,001). Conclusion(s): The frequency of local adverse effects, particularly pain at injection site, was high. AEs were more frequent with ChAdOx1, especially after the first dose. The use of the immunizers dis not change the degree of inflammatory activity of the disease. In patients with RA, ChAdOx1 was more immunogenic than CoronaVac. .
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Working outside of the employer's physical space using information and communication technology can be labeled as telework. With the Covid-19 pandemic, telework assumed an unprecedented relevance with substantial impact for the future. Therefore, the development of assessment scales that allow a better comprehension of telework is essential. In this study, the factor structure, reliability, and validity of the Impact of Telework on Career Scale (ITCS) were assessed tested on 533 workers, and confirmatory analyses were performed on 532 remote workers. Results suggested good psychometric properties and a two-factor structure, Work-Related Well-Being, and Psychological Well-Being. Furthermore, this Portuguese sample considered that telework has little impact on the connection with colleagues, employers, and the probability of being promoted, but it can promote work-related satisfaction and performance, as well as reduce work-family conflict. Implications for scale usage are discussed.
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BACKGROUND: COVID-19 has significantly affected patients with cancer and revealed unanticipated challenges in securing optimal cancer care across different disciplines. The European Society for Medical Oncology COVID-19 and CAncer REgistry (ESMO-CoCARE) is an international, real-world database, collecting data on the natural history, management, and outcomes of patients with cancer and SARS-CoV-2 infection. METHODS: This is the 2nd CoCARE analysis, jointly with Belgian (Belgian Society of Medical Oncology, BSMO) and Portuguese (Portuguese Society of Medical Oncology, PSMO) registries, with data from January 2020 to December 2021. The aim is to identify significant prognostic factors for COVID-19 hospitalization and mortality (primary outcomes), as well as intensive care unit admission and overall survival (OS) (secondary outcomes). Subgroup analyses by pandemic phase and vaccination status were carried out. RESULTS: The cohort includes 3294 patients (CoCARE: 2049; BSMO: 928, all hospitalized by eligibility criteria; PSMO: 317), diagnosed in four distinct pandemic phases (January to May 2020: 36%; June to September 2020: 9%; October 2020 to February 2021: 41%; March to December 2021: 12%). COVID-19 hospitalization rate was 54% (CoCARE/PSMO), ICU admission 14%, and COVID-19 mortality 22% (all data). At a 6-month median follow-up, 1013 deaths were recorded with 73% 3-month OS rate. No significant change was observed in COVID-19 mortality among hospitalized patients across the four pandemic phases (30%-33%). Hospitalizations and ICU admission decreased significantly (from 78% to 34% and 16% to 10%, respectively). Among 1522 patients with known vaccination status at COVID-19 diagnosis, 70% were non-vaccinated, 24% had incomplete vaccination, and 7% complete vaccination. Complete vaccination had a protective effect on hospitalization (odds ratio = 0.24; 95% confidence interval [0.14-0.38]), ICU admission (odds ratio = 0.29 [0.09-0.94]), and OS (hazard ratio = 0.39 [0.20-0.76]). In multivariable analyses, COVID-19 hospitalization was associated with patient/cancer characteristics, the first pandemic phase, the presence of COVID-19-related symptoms or inflammatory biomarkers, whereas COVID-19 mortality was significantly higher in symptomatic patients, males, older age, ethnicity other than Asian/Caucasian, Eastern Cooperative Oncology Group performance status ≥2, body mass index <25, hematological malignancy, progressive disease versus no evident disease, and advanced cancer stage. CONCLUSIONS: The updated CoCARE analysis, jointly with BSMO and PSMO, highlights factors that significantly affect COVID-19 outcomes, providing actionable clues for further reducing mortality.
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COVID-19 , Neoplasias , Masculino , Humanos , SARS-CoV-2 , Prueba de COVID-19 , Factores de Riesgo , Neoplasias/epidemiología , Neoplasias/terapia , Oncología Médica , Sistema de RegistrosRESUMEN
Remote controlled laboratories had a great push during the COVID-19 pandemic. In fact, they were already out there but lacking in visibility. This external trigger pushed the academy to face a global challenge to start offering remote experiments more consistently and maturely. Instituto Superior Técnico (IST) has been offering several remote experiments since 2000 but with the need for an update due to technological aging. As such, the framework for remote experiments in education (FREE) was created based on new web technologies. In addition to the most diverse experiments that had already been developed, FREE includes two experiments that aimed at advanced-level physics students: the Langmuir probe and the electromagnetic (EM) cavity. Both allow users to configure the various parameters and to access the results in real time or check back later. All this access is done using a browser (on a PC or mobile phone) without the need to install additional software. The results of an experimental execution are stored in a database and are downloadable, allowing users to do various analyses and to determine the corresponding plasma density and temperature. In this paper, we will introduce how FREE was used in the implementation of both experiments and give an insight into their didactic approach, such as: (i) how to perform an experimental execution, (ii) the typical data set obtained with, and (iii) the corresponding analysis necessary for the user to retrieve information from it. © 2023 Pedro A. Mendes Rossa et al., published by Sciendo.
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Over the last two years, the COVID-19 pandemic has affected hundreds of millions of people around the world. As in many crises, people turn to social media platforms, like Twitter, to communicate and share information. Twitter datasets have been used over the years in many research studies to extract valuable information. Therefore, several large COVID-19 Twitter datasets have been released over the last two years. However, none of these datasets contains only Portuguese Tweets, despite the Portuguese Language being reported as one of the top five languages used on Twitter. In this paper, we present the first large-scale Portuguese COVID-19 Twitter dataset. The dataset contains over 19 million Tweets spanning 2020 and 2021, allowing the entire pandemic to be analyzed. We also conducted a sentiment analysis on the dataset and correlated the various spikes in Tweet count and sentiment scores to various news articles and government announcements in Portugal and Brazil. The dataset is available at: https://github.com/bioinformatics-ua/Portuguese-Covid19-Dataset © 2022 IEEE.
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Working outside of the employer's physical space using information and communication technology can be labeled as telework. With the Covid-19 pandemic, telework assumed an unprecedented relevance with substantial impact for the future. Therefore, the development of assessment scales that allow a better comprehension of telework is essential. In this study, the factor structure, reliability, and validity of the Impact of Telework on Career Scale (ITCS) were assessed tested on 533 workers, and confirmatory analyses were performed on 532 remote workers. Results suggested good psychometric properties and a two-factor structure, Work-Related Well-Being, and Psychological Well-Being. Furthermore, this Portuguese sample considered that telework has little impact on the connection with colleagues, employers, and the probability of being promoted, but it can promote work-related satisfaction and performance, as well as reduce work-family conflict. Implications for scale usage are discussed. © 2022 AIDEP. All rights reserved.
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The text discusses the vulnerability of basic education geography students and teachers due to the working conditions and the lack of access to the study of socio-environmental disaster risks, elements absent in the text book. The reflections are supported by results of research and teaching carried out by researchers from federal universities of Minas Gerais, in the field of geography education, during 2020 and 2021. The surveys wer ecarried out during the Supervised Internship and the Teaching Practices under graduation courses, all carried out online. In this context, question naires were applied to 46 Geography teachers from several municipalities in the southern and south eastern regions of Minas Gerais. The discussion of the results and there flections presented here are based on the concept of Power fulk nowledge, on the idea of an intellectual teacher, on the discussion of culture bodies and on the notion of socio-environmental risks. The results show that the teaching and learning conditions, school contentand internet access in the time of Covid-19 pandemic contributed to thein creased vulnerability of students in the face of socio-environmental risks due to the lack of access to knowledge on the subject and to the students' socioeconomic reality. © 2022 Universidade Federal do Parana. All rights reserved.
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The novel coronavirus (SARS-CoV-2), which was isolated in January 2020, emerged as a result of natural evolution and has already infected millions of people around the world due to its extensive human-to-human transmission capacity. Highlighting the clinical manifestations, pathology and immune response against the SARS-CoV-2 infection process, this review study was con-ducted through a comprehensive bibliographic search of academic papers that are available online at the following databases Science Direct, Pub Med, ACS Publications, Nature, BioRxiv and Me-dRxiv. According to the analyzed works, people infected with SARS-CoV-2 may display fever and dry cough as the main clinical symptoms and they may also present breathing difficulty, muscle pain (myalgia), chills, lack of appetite, fatigue, sore throat, altered consciousness, diarrhea, vomit-ing, nasal discharge and syncope. When considering the immune status of patients with COVID-19, it is highlighted that hypercytokinemia contributes to the severity that can even result in death. Lymphopenia is the most frequent prognosis described in cases of COVID-19. Thus, a de-tailed understanding of the specific inflammatory pathways that result in the pathology of COVID-19 is crucial for the immediate development of clinical therapeutic approaches.Copyright © 2021 Bentham Science Publishers.
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Introduction: Patients with chronic kidney disease (CKD) have a higher risk for infection caused by the new coronavirus (COVID-19). The COVID-19 pandemic and social isolation contributed to the adaptation to new health promotion and education tools, including virtual methods. The aim of this study is to analyze the guidelines made through the Renal Health profile on Instagram during the COVID-19 pandemic to patients with CKD. Method(s): This is a quantitative, descriptive study, with the analysis of posts, comments and likes, carried out on the Renal Health (@renal_health) Instagram profile, an educational project based in Brazil, initiated as part of an ISN Clinical Research Program Project, which addresses kidney health, from February 2020 to May 2022, during the COVID-19 pandemic. Result(s): Currently, the Renal Health Instagram profile (https://www.instagram.com/renal_health/) has 1333 publications and more than 10,000 followers. It is a profile administered by a nurse, a nephrologist and a team of public health researchers at the University of Fortaleza, Brazil. A total of 106 posts about COVID-19 were analyzed, covering news about the pandemic, guidelines on prevention and vaccination, association between COVID-19, CKD and transplantation, among others. There were 13,815 likes and 1,068 comments. The most liked post (n = 696) was a photo with a news item: "InCor discharges Covid patient with transplanted lung". Among the comments, it was possible to observe several compliments, reports of patients with CKD and kidney transplants, as well as doubts, which were answered by the team that maintains the profile. The most commented post was also a news item: "Hospital denies transplant to unvaccinated patients", with 146 comments. Conclusion(s): The general population's interest in the association between COVID-19 and kidney disease is evident. It is important to point out the role of the profile as an online educational tool that helps in clarifying doubts about the new coronavirus, in addition to acting as an easy and practical way to acquire knowledge from reliable sources, regarding the risks that patients with kidney diseases have when contracting the virus, as well as many other relevant subjects, always emphasizing the relevance of preventive measures, including vaccination. From the study, it is noticeable that, during the pandemic, there were a large number of clarified doubts, as well as positive feedbacks about the platform. Therefore, the Renal Health profile proved to be an important health education mechanism during the pandemic. No conflict of interestCopyright © 2023
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Investigating efficacy beliefs for coping with COVID-19 can be helpful when proposing interventions that contribute to mitigate the disease. Six scales of efficacy beliefs for coping with COVID-19 were built: self-efficacy;family and community collective efficacy;and proxy efficacy to the municipal, state and federal governments. To obtain evidence of validity based on the internal structure and reliability estimates of these measures, 518 participants completed an online form. Exploratory factor analysis revealed that all scales had a unidimensional structure. Cronbach's alphas ranged from .819 to .968. Although positive correlations predominated between the scores of the six scales, the magnitudes were, in general, weak or moderate, showing that they were distinct constructs. These scores differed from each other, with levels of efficacy decreasing as individual control over the actions necessary to mitigate COVID-19 decreased. Thus, the six scales initially presented satisfactory psychometric properties. Study-related limitations, implications and recommendations are also presented. © 2022 Associacao Portuguesa de Psicologia. All rights reserved.
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Introduction: Kidney transplant (KT) recipients have a high risk for adverse outcomes from infections, such as COVID- 19. Methods: We have retrospectively reviewed all KT recipients with documented COVID-19 between March 1, 2020, and March 15, 2021, and analyzed patients' characteristics, clinical course, treatment, and outcomes. Results: We identified 123 patients, 72% were male, with a mean age of 54.5±13.0 years. Twenty percent were asymptomatic, 7% had a nosocomial transmission, and 36% of the remainder required hospitalization. Almost all admitted patients received oxygen, 30% required invasive mechanical ventilation (IMV), more than a half had acute kidney injury, with 10% requiring dialysis, and 20% died. Incidence was comparable to that of the Portuguese population, but the mortality rate was almost four times higher (SMR of 3.768 (95% CI:1.723-7.154). Higher body mass index (OR 1.275, P=0.001), lower baseline graft function (OR 0.968, P=0.015), and nosocomial transmission (OR 13.836, P=0.019) were associated with oxygen demand, whereas female gender (OR 3.801, P=0.031) and lower baseline kidney graft function (OR 0.955, P=0.005), but not body mass index, were associated with IMV and/or death. Conclusion: Mortality rate in KT patients was higher than in the general population and lower baseline kidney function was the most consistent marker for adverse outcomes.
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Even after over 2 years of the COVID-19 pandemic, research on rapid, inexpensive, and accurate tests remains essential for controlling and avoiding the global spread of SARS-CoV-2 across the planet during a potential reappearance in future global waves or regional outbreaks. Assessment of serological responses for COVID-19 can be beneficial for population-level surveillance purposes, supporting the development of novel vaccines and evaluating the efficacy of different immunization programs. This can be especially relevant for broadly used inactivated whole virus vaccines, such as CoronaVac, which produced lower titers of neutralizing antibodies. and showed lower efficacy for specific groups such as the elderly and immunocompromised. We developed an impedimetric biosensor based on the immobilization of SARS-CoV-2 recombinant trimeric spike protein (S protein) on zinc oxide nanorod (ZnONR)-modified fluorine-doped tin oxide substrates for COVID-19 serology testing. Due to electrostatic interactions, the negatively charged S protein was immobilized via physical adsorption. The electrochemical response of the immunosensor was measured at each modification step and characterized by scanning electron microscopy and electrochemical techniques. We successfully evaluated the applicability of the modified ZnONR electrodes using serum samples from COVID-19 convalescent individuals, CoronaVac-vaccinated with or without positive results for SARS-CoV-2 infection, and pre-pandemic samples from healthy volunteers as controls. ELISA for IgG anti-SARS-CoV-2 spike protein was performed for comparison, and ELISA for IgG anti-RBDs of seasonal coronavirus (HCoVs) was used to test the specificity of immunosensor detection. No cross-reactivity with HCoVs was detected using the ZnONR immunosensor, and more interestingly, the sensor presented higher sensitivity when compared to negative ELISA results. The results demonstrate that the ZnONRs/spike-modified electrode displayed sensitive results for convalescents and vaccinated samples and shows excellent potential as a tool for the population's assessment and monitoring of seroconversion and seroprevalence.
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Software development teams depend on the constant and varied use of technological tools that contribute to the fluidity of development activities. The communication channels provided by these tools contribute to the participatory culture of software development, where requirements include getting involved, learning and co-producing the code. However, the choice of channels to support development is still an open question in the scientific community. Through an investigation of closed remote software teams from a large public educational institution in Brazil during the COVID-19 Pandemic, we identified their preferred communication channels and analyzed them to learn how to improve collaboration. We also drew some comparison with social developers and took a look at the challenges that these channels impose and solutions adopted to mitigate these problems. © 2023 ACM.
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Lung cancer patients with COVID-19 present an increased risk of developing severe disease and, consequently, have poor outcomes. Determining SARS-CoV-2-host interactome in lung cancer cells and tissues, infected or uninfected with SARS-CoV-2, may reveal molecular mechanisms associated with COVID-19 development and severity in lung cancer patients. Here, we integrated transcriptome data of lung tumors from patients with small- or non-small cell lung cancer (SCLC and NSCLC) and normal lung and lung cancer cells infected with SARS-CoV-2. We aimed to characterize molecular mechanisms potentially associated with COVID-19 development and severity in lung cancer patients and to predict the SARS-CoV-2-host cell interactome. We found that the gene expression profiles of lung cell lines infected with SARS-CoV-2 resemble more primary lung tumors than non-malignant lung tissues. In addition, the transcriptomic-based interactome analysis of SCLC and NSCLC revealed increased expression of cancer genes BRCA1 and CENPF, whose proteins are known or predicted to interact with the SARS-CoV-2 spike glycoprotein and helicase, respectively. We also found that TRIB3, a gene coding a putative host-SARS-CoV-2 interacting protein associated with COVID-19 infection, is co-expressed with the up-regulated genes MTHFD2, ADM2, and GPT2 in all tested conditions. Our analysis identified biological processes such as amino acid metabolism and angiogenesis and 22 host mediators of SARS-CoV-2 infection and replication that may contribute to the development and severity of COVID-19 in lung cancers.
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This article deals with the differential distribution of death in the face of viral epi-demics and pandemics. We will take the current Sars-CoV-2 pandemic in conjunc-tion with the HIV epidemic in order to understand how barriers that divide hu-mans into groups, by which it is decided who can or cannot die of a viral disease. Thinking from Donna Haraway's feminism and critique of human exceptionalism, her theory is articulated with the notions of biopolitics, necropolitics and framing, in order to situate the relationships between some humans and these viruses, con-sidering crossings such as race, gender and sexuality. It is possible to understand that, even without any scientific evidence that justify fatal encounters between some humans and viruses, the stories produced about these pathogens guide those who live or die in contact with them.
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The covid-19 pandemic brought the opportunity to accelerate the acceptance and usage of existing behaviors and innovations by society and the market. Amongst these innovations, e-commerce food stands out, allowing food companies to redesign their models to face the demand during the pandemic. This research aims to recognize the profile of online food buyers within Portugal and understand the determinants of online food purchase intention in the context of the pandemic. The methodology applied is quantitative, using the Partial Least Squares method to test the hypotheses formulated by the proposed structural model. The data used resulted from applying an online questionnaire to 358 food consumers in Portugal. The results show that situational factors directly related to eating behavior positively impact the online food shopping experience, increasing the intention to purchase food online during covid-19. Concerning the profile of the e-consumer, it seems that owning a vehicle negatively influences the intention to purchase food in e-commerce, as opposed to the level of income, which is a positive factor. On the theoretical side, this research contributes to the literature by contributing on the theme of food e-commerce in a pandemic time, which is currently very scarce. As for practical contributions, through the identification of the trends in consumer behavior during and after the pandemic, companies can better anticipate and prepare for new consumer needs and profiles, consequently developing new strategies and increasing their e-commerce sales. Since Portugal has a small digital population and less than 35% of digital natives, the prominence of studies in this area is minor. The current research is original and innovative, as studies that analyze consumer behavior in food e-commerce in this country, specifically during a pandemic, are scarcer. © 2023, Universidad Nacional de Colombia. All rights reserved.